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Cardiovascular Outcomes of Low Testosterone

A research group out of the University of Colorado in Denver is looking for men who are willing to participate in a study that seeks to learn more about the association between low testosterone and cardiovascular disease in older men. To be eligible to participate in the study you must be a male between the ages of 50 and 75 with an overall good health history that is devoid of cancer, diabetes, heart disease, high blood pressure, and high cholesterol.

"In some men as they get older, testosterone levels fall below the normal range as that seen in young men. Also, as men get older cardiovascular health can deteriorate which can lead to high blood pressure and heart disease. In this research study, “Cardiovascular consequences of hypogonadism in men”, we want to find out what causes cardiovascular health to deteriorate in older men and whether older men who have low testosterone have worse cardiovascular health than men with normal testosterone."

Furthermore, researchers are hoping to discover the cardiovascular effects in men with normal testosterone levels when their levels are reduced for a brief time period. Specifically, they want to know if the decline in cardiovascular health in aging men who testosterone deficient is related to mitochondrial damage, as mitochondria are the main energy sources of our body's cells. 

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To express interest in being a study participant you can send an email to This email address is being protected from spambots. You need JavaScript enabled to view it..


FOX NEWS: 10 Warning Signs of Low Testosterone You Should Never Ignore

The team at FoxNews.com recently published an article that discusses the 10 most concerning warning signs associated with low testosterone. We've briefly listed the 10 warning signs below. Please visit the source article to read about these warning signs in entirety.

  • Decrease libido
  • Weight gain
  • Erectile dysfunction
  • Constant fatigue
  • Trouble sleeping
  • Difficulty concentrating
  • Depression or extreme sadness
  • Gynecomastia (male breast growth)
  • Aches & Pains
  • Osteoporosis

Source article: http://www.foxnews.com/health/2016/07/18/10-warning-signs-low-testosterone-men-should-never-ignore.html

TRT Safe for Men With Prostate Cancer, Study Says

Renal & Urology News just published an article saying that testosterone replacement therapy (TRT) does not make worse the oncologic outcomes for men with low testosterone and prostate cancer. The article cites the findings presented at the Canadian Urological Association meeting last week in Vancouver.

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About the Study

Researchers and doctors, led by Jesse Ory of the University of British Columbia, were able to identify 83 men that had both hypogonadism (Low T) and prostate cancer. These men were administered testosterone replacement therapy. Of the group, 50 men were subject to radiation therapy, 22 underwent radical prostatectomy, 8 were places on surveillance, 1 had cryotherapy, and another was treated with high-intensity ultra sound. The average age of the patients studied was 75.5 years old. The average follow up time was forty one months.

"The investigators observed an increase in both testosterone and PSA levels in the entire cohort, but only patients with low-risk PCa had a statistically significant increase in PSA. PSA increased in the AS patients, but none of these patients were upgraded to a higher Gleason score on subsequent prostate biopsies and none have yet gone on to definitive treatment, the researchers reported. No RP patient experienced biochemical recurrence, but 3 RT patients (6%) did, as defined by 2006 Phoenix criteria (PSA nadir plus 2 ng/mL)." - Renal & Urology News

Learn more about this study and new developments by following the news from the Canadian Urological Association Meetings: http://www.renalandurologynews.com/canadian-urological-association/section/1058/

Testosterone Therapy May Increase Muscle Mass in Men With Cirhossis, Study Says

HEALIO - A recent article published at healio.com cites research which indicates success in increasing muscle and bone mass in men with cirrhosis and low testosterone by administering testosterone replacement therapy. These findings have given hope to many who believe they will now be able to increase survival for patients with cirrhosis with testosterone therapy.

“This trial demonstrates for the first time that testosterone therapy can safely increase muscle mass in men with cirrhosis who have low baseline testosterone levels and thus represents the first evidence-based therapy for sarcopenia in cirrhosis.” - Marie Sinclair, MD

The researchers that led the study utilized 101 participants that had been diagnosed with cirrhosis and low serum testosterone. These participants were randomly assigned either testosterone replacement therapy for one year or a placebo and were observed and monitored at the 6 month and 12 month marks. After one year, it appeared the appendicular lean mass was higher in those who were administered testosterone. These same men also registered a higher total lean mass compared to those who were given the placebo.

"Though not conclusive, these findings give us reason to be cautiously optimistic as we seek to help our brothers suffering with cirrhosis." - R. Mondello, Tornado Shelters in Fort Worth

Read more by visiting this article's source: http://www.healio.com/hepatology/cirrhosis-liver-failure/news/online/%7B9591edd8-168c-4ed1-b774-ad1422f3bac3%7D/testosterone-therapy-increases-muscle-mass-in-men-with-cirrhosis

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